I think you should refresh targeting settings regularly to keep up with changes in user behavior. This can help you stay on track and make sure your campaigns are always performing well. Refreshing your targeting settings often also helps you find new opportunities and avoid wasting budget on settings that aren't working. Some people refresh their settings every few weeks, while others do it monthly. The key is to find a rhythm that works for you and your campaigns. What do you think about refreshing targeting settings?